Endocrine Abstracts

Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited endocrinopathy characterized by tumours of the parathyroid glands, adenohypophyseal and pancreatic tumours. We present a case of a young, 24 years old female patient with a positive familial background for MEN1 (on the fathers’ side of the family). She is one of two sisters with determined heterozigocity of the MEN 1 gene (Exon 2, codon 111). At the age of 12, insulinoma of the head of the pancreas was diagnos...

Introduction: Hypercalcaemia in acromegaly can be a result of several pathophysiological mechanisms. Multiple endocrine neoplasia type 1 (MEN1) syndrome, mitogenic effect of hyperactivated GH–parathyroid gland axis, i.e. primary hyperparathyroidism and hypercalcaemia mediated by elevated 1,25-dihydroxyvitamin D should be considered.Case report: We describe a case of acromegaly associated with primary hyperparathyroidism. A 52-year-old female was dia...

Vitamin D deficiency is common and various supplementations regimens are in use. The purpose of this audit was to compare the efficacy of two short-term colecalciferol loading regimens in treating Vitamin D deficiency. Sixty-four consecutive patients with serum 25OH VitaminD ≤30 nmol/L were assigned to 12 or 16 weeks treatment with 40,000 IU colecalciferol orally once a week. The main endpoint was to identify which duration of treatment is adequate for achievement of suf...

Introduction: Thyroid hormone deficiency can lead to the impairment of cardiac function. Whether subclinical hypothyroidism (ScH) is a risk factor for left ventricular (LV) dysfunction is controversial. Aim of the study was to assess whether ScH is associated with LV systolic and diastolic dysfunction and it’s reversibility after treatment with L-thyroxine.Material and methods: Twenty-seven consecutive patients with newly diagnosed Sc...

Introduction: Hyponatremia is rarely reported as a delayed complication of transsphenoidal resection of pituitary adenoma. Severe hyponatraemia can cause potentially fatal conse-quences.Material and methods: A 34 year old patient was admitted as an urgent case at the Clinic of Endocrinology, with symptoms and signs of Addisonian crisis (dizziness, headaches, nausea, vomiting, hypotension), with muscular weakness and muscle aches, tingling hands and confu...

Sixteen percent of parathyroid adenomas can be situated in an ectopic location. Ectopic parathyroid glands result from aberrant migration during early stages of development, and lack of successful identification may lead to lack of success in parathyroid surgery. These glands are most frequently found in the anterior mediastinum, in association with the thymus or the thyroid gland. Ectopic parathyroid glands are a major cause of persistent and recurrent hyperparathyroidism.</p...

Introduction: Ectopic Cushing’s syndrome caused by ectopic ACTH secretion are under-diagnosed.Case report: A 50 years old male patient is hospitalized for severe hypokalaemia and diabetes. Last 6 months he had a history of chest pain, prolonged cough, general weakness, difficulties climbing stairs, confusion, loss of consciousness. Previously, he was hospitalized in psychiatric hospital for psychotic alterations, in cardiology for high blood pressur...

McCune–Albright syndrome (MAS) is characterized by fibrous dysplasia (FD), cutaneous cafe-au-lait pigmentation and autonomous hyper-secretory endocrinopathies. Association of acromegaly with MAS is very rare. We present a case of a 35-year-old men with MAS, diagnosed with poly-ostotic fibrous dysplasia at the age of 12, no history of premature puberty, with GH secreting cystic macroadenoma 40×35×45 mm big and clinical picture of acromegaly, hypopituitarism and b...

Objective: Surgery is considered first-line treatment for pituitary GH secreting macroadenoma. Since surgical removal of the pituitary tumor is subtotal, medical treatment has become the mainstay of acromegaly. The aim of our study was to assess the effect of octreotide LAR (OCT-LAR) therapy in patients with acromegaly.Patients and methods: Ten acromegalic patients were treated with OCT-LAR 20 mg/28 days. The effect was evaluated after 12 months of treat...

Background: The most striking change in diabetes over recent years has been the convergence of previously distinctive phenotypes. Recently diagnosed children are younger, taller and with greater BM. Pediatric endocrinologists are facing with children presenting mixed signs of both diabetes types. So called hybrid diabetes, or type 1½ has insulin resistance in type 1 phenotype and vice versa autoimmunity in obese children.Patients and methods: Ten ch...